Cranberry
Vaccinium macrocarpon Aiton; the small cranberry, Vaccinium oxycoccus L., is the marsh-wort or fen-berry of Folkard and the Ojibwe swamp berry bush; in pharmacy Vaccinii macrocarpi fructus
- Known today as
- Vaccinium macrocarpon, an evergreen shrub whose red berries are, by the European Medicines Agency’s account, 88 per cent water. Massachusetts is one of the primary growing areas of the native plant. Its smaller relative V. oxycoccus, which the agency’s assessment report also counts among the cranberries, is the plant of the older European and Ojibwe sources below.
- Kind
- Plant, in 1 older authority
- Constituents
- proanthocyanidins, anthocyanin, vitamin C
- Earliest authority here
- Huron H. Smith, Ethnobotany of the Ojibwe Indians (1932)
- In other databases
- Plants of the World Online · GBIF · Wikidata
Caution. Not with warfarin, whose effect cranberry may strengthen, nor with tacrolimus, whose blood levels fell in a kidney-transplant patient drinking cranberry juice. Not recommended for men, for pregnant women, or under eighteen, since their urinary symptoms need a doctor; anyone with kidney disease and recurrent infections needs medical supervision, and cranberry concentrate is high in oxalate, a risk for those with a history of urinary stones. See a doctor if fever, painful urination, spasms, or blood in the urine appear. Nausea, diarrhoea, indigestion, urticaria, and rash have been reported. LiverTox finds no link to liver injury and notes that cranberry may reduce the levels and effect of proton pump inhibitors and H2 blockers.
Cranberry: what was it used for?
A food first. The assessment report records that Native Americans ate wild cranberries for centuries in pemmican, crushed berries with fat and dried meat, though there is no recorded medicinal use among the tribes of Massachusetts; other peoples in Canada made a tea of the branches for pleurisy and poulticed wounds with the fruit, and First Nations people in Quebec applied crushed cranberries to sores. Seventeenth-century writers gave it for blood disorders, stomach ailments, fevers, and scurvy, and in 1905 the raw fruit was still a domestic poultice for erysipelas, swollen glands, ulcers, and tonsillitis.
Cranberry: what does modern science say?
The European Medicines Agency’s herbal committee accepts the fruit as a traditional herbal medicine, “exclusively based upon long-standing use,” to relieve the symptoms of mild recurrent lower urinary tract infections in women, such as burning or frequent urination, and to prevent recurrent uncomplicated lower urinary tract infections in women, in both cases after a doctor has excluded serious conditions (monograph of 2022). Its assessment report names the proanthocyanidins, chiefly chains of four or five epicatechin units, and the anthocyanin pigments among the constituents, with high levels of vitamin C. The Cochrane reviews of 2023 divide the two uses. For prevention, fifty studies in 8,857 participants support cranberry products in reducing symptomatic, culture-verified infections in women with recurrent infections, in children, and in people susceptible after medical interventions, but not in the elderly, in people with bladder-emptying problems, or in pregnancy. For treatment, the review found no randomised trials at all, and so “no good quality evidence to suggest that it is effective for the treatment of UTIs.”
Pharmacognosy & Toxicology
- Constituents
- proanthocyanidinschiefly chains of four or five epicatechin units
- anthocyaninthe red pigments
- vitamin C ChEMBLat high levels
- Mechanism
- Not established in the sources read for this entry.
- Standing
- European Union herbal monograph (2022): traditional use, “exclusively based upon long-standing use,” for mild recurrent lower urinary tract infections in women and their prevention. Cochrane reviews (2023) support prevention in some groups and find no trials of treatment.
- European Medicines Agency, Committee on Herbal Medicinal Products. European Union herbal monograph on Vaccinii macrocarpi fructus (Cranberry). EMA/HMPC/49135/2017, 23 November 2022. Read in full · the text read
- European Medicines Agency, Committee on Herbal Medicinal Products. Assessment report on Vaccinii macrocarpi fructus. EMA/HMPC/517879/2016, 23 November 2022. Read in part · the text read
- Williams G, et al. (2023). Cranberries for preventing urinary tract infections. The Cochrane database of systematic reviews. PMID 37947276. Abstract read · the text read
- Jepson RG, et al. (2023). Cranberries for treating urinary tract infections. The Cochrane database of systematic reviews. PMID 38096261. Abstract read · the text read
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, “Cranberry.” National Institute of Diabetes and Digestive and Kidney Diseases, updated 2023. NCBI Bookshelf. Read in full · the text read
The abstract of each source, beneath its citation. For Club members. About the Club or sign in.
Constituent names open the compound’s record at PubChem, and “ChEMBL” beside a name opens its record at ChEMBL, the European Bioinformatics Institute’s database of bioactive molecules. Where a mechanism line was checked against ChEMBL (ChEMBL 37, read 1 October 2026), the check is shown with the measured value and its source paper, or says plainly that nothing has been measured. Doses are as the references give them, for description only; this is not medical advice. Each source carries the result of its check against Crossref, PubMed, or the authority’s page: see Verification.
Cranberry: what lore surrounds it?
Folkard, writing of the small cranberry, says the Druids called the plant Samolus and gathered it with great ceremony, after a fast, without looking back while picking it, and with the left hand only, and that it was held especially good against the diseases of swine and cattle. New England folk practitioners, the assessment report adds, used boiled cranberries with seal oil to ease attacks of the gall bladder.
Cranberry: what did the older authorities say?
- Huron H. Smith, Ethnobotany of the Ojibwe Indians (1932)
- Of the small cranberry, Vaccinium oxycoccus, which the Ojibwe called by a name meaning ‘swamp berry bush,’ Smith recorded “A tea for a person who is slightly ill with nausea,” and that white men had used its bitter, astringent leaves in diarrhoea and diabetes and for purifying the blood.
Sources
- Smith, H. H. (1932). Ethnobotany of the Ojibwe Indians, Cranberry (Vaccinium oxycoccus). Bulletin of the Public Museum of the City of Milwaukee 4. Project Gutenberg, 49527. Read in part · the text read
- Folkard, R. (1884). Plant Lore, Legends, and Lyrics, “Cranberry.” Project Gutenberg, 44638. Read in part · the text read
- European Medicines Agency, Committee on Herbal Medicinal Products. European Union herbal monograph on Vaccinii macrocarpi fructus (Cranberry). EMA/HMPC/49135/2017, 23 November 2022. Read in full · the text read
- European Medicines Agency, Committee on Herbal Medicinal Products. Assessment report on Vaccinii macrocarpi fructus. EMA/HMPC/517879/2016, 23 November 2022. Read in part · the text read
- Williams G, et al. (2023). Cranberries for preventing urinary tract infections. The Cochrane database of systematic reviews. PMID 37947276. Abstract read · the text read
- Jepson RG, et al. (2023). Cranberries for treating urinary tract infections. The Cochrane database of systematic reviews. PMID 38096261. Abstract read · the text read
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, “Cranberry.” National Institute of Diabetes and Digestive and Kidney Diseases, updated 2023. NCBI Bookshelf. Read in full · the text read
Verification
- Checked
- October 1, 2026
- Passes
- Every sentence read against its sources, in the pass over the remaining 343 entries
- The Standing line checked against the authority it names (EMA, WHO, FDA, CITES, Commission E)
- Every dated or regulatory claim checked by category across the database
- Sources
- 7 cited: 2 read in full, 3 read in part, 2 abstract read. 2 with the abstract on file.
- Corrections
- None were needed.
What was checked, how, and what was found is set out on the Verification page. A checked source is one whose record was found; it does not make the entry medical advice.
Club members can point at a technical term in this entry, such as a constituent, an action, or a word of Jung’s, to read its definition from the source. The Club.
Cite This Entry
Version 1 · first published October 16, 2026
- Chicago
“Cranberry.” In Materia Medica, edited by B. C. P. Statema. Version 1. The Thinking Press, 2026–. Last modified October 16, 2026. https://thethinkingpress.org/materia-medica/cranberry.
- MLA
“Cranberry.” Materia Medica, edited by B. C. P. Statema, version 1, The Thinking Press, 16 Oct. 2026, thethinkingpress.org/materia-medica/cranberry. Accessed 17 Oct. 2026.
- APA
Cranberry. (2026, October 16). In B. C. P. Statema (Ed.), Materia medica (Version 1). The Thinking Press. Retrieved October 17, 2026, from https://thethinkingpress.org/materia-medica/cranberry
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See Also
Sharing proanthocyanidins, vitamin C
Cupressus sempervirens · Uncaria tomentosa · Paullinia cupana · Prunus spinosa · Lepidium sativum · Oxalis acetosella · Rosa gallica · Sorbus aucuparia
Drawing on the same sources: Smith, Folkard
Guelder rose · Corn silk · Jewelweed · Cumin · Coriander · Cyclamen, greater · the bibliography →
Nearby in the alphabet
Crow’s gall (The bile of a crow) · Cramp rings (made from gold and silver offered at the cross) · Crucifix (The image of Christ on the Cross) · Crabs’ eyes (Chalky stones from the stomachs of crayfish) · Cubeb (a Javanese pepper whose berries keep a little stalk, like a tail) · Cowslip (Primula veris) · Couch grass
Historical description, not medical advice.
