Kava

Kava kava, ava, ava pepper, intoxicating pepper; Macropiper methysticum Miq.; Piper methysticum G. Forst.; in pharmacy Piperis methystici rhizoma

Known today as
Piper methysticum, a shrub of the pepper family Piperaceae about six feet high, which King’s Dispensatory describes as somewhat resembling bamboo in growth, native and commonly cultivated in the South Sea Islands, with heart-shaped leaves and small flowers on slender spikes. The drug is the peeled, dried rhizome, in Grieve’s description whitish or grey-brown, starchy, with a faint pleasant odour and a bitter, pungent, aromatic taste. Its active constituents, LiverTox records, are the kavapyrones or kavalactones.
Kind
Plant, in 1 older authority
Constituents
kavalactones
Earliest authority here
King’s American Dispensatory (1898)
In other databases
Plants of the World Online · GBIF · Wikidata

Caution. LiverTox rates kava a well-known cause of clinically apparent liver injury, which “can be severe and even fatal”; its use has been banned or restricted in countries including Germany, Switzerland, France, Canada, and Great Britain, though some dispute the evidence and blame adulterants or other drugs, and some severe cases are convincing. Its abuse potential is low but not absent: a 2024 case report describes a man who, after weeks of escalating use, was admitted after a fall while intoxicated and developed a withdrawal delirium treated with phenobarbital, the first such report its authors knew of. Headache, dizziness, drowsiness, and diarrhoea are its commonest side effects.

Kava: what was it used for?

A ceremonial and social drink, and later a medicine for anxiety. LiverTox records that it has been used for centuries as a recreational and ceremonial drink in Oceania, its kavalactones having effects similar to alcohol, “such as relaxation, talkativeness, and euphoria.” Grieve records that the natives drank a liquor from the rhizome “before important religious rites,” and that in Western medicine it had been used against gonorrhoea and other complaints of the genito-urinary tract.

Kava: what does modern science say?

The Cochrane review of 2003, of eleven trials in 645 people, found that kava extract reduced anxiety scores against placebo and “appears to be an effective symptomatic treatment option for anxiety,” relatively safe in the short term though more information on long-term safety was needed. The European Medicines Agency’s herbal committee, however, declined any monograph on the rhizome (public statement of 2017): it found toxicological concerns, carcinogenic potential in animals, in relation to one preparation, and noted spontaneous reports of liver reactions, including liver failure leading to transplants and deaths, and the withdrawal of products in some member states, and judged the balance of benefit and risk unfavourable. A 2025 review of 197 records found its role both in liver toxicity and in reducing anxiety still unclear, while kava remains socially, culturally, and economically important to the Pacific Islands.

Kava: is it poisonous?

Yes, in some form or dose. LiverTox rates kava a well-known cause of clinically apparent liver injury, which “can be severe and even fatal”; its use has been banned or restricted in countries including Germany, Switzerland, France, Canada, and Great Britain, though some dispute the evidence and blame adulterants or other drugs, and some severe cases are convincing. Its abuse potential is low but not absent: a 2024 case report describes a man who, after weeks of escalating use, was admitted after a fall while intoxicated and developed a withdrawal delirium treated with phenobarbital, the first such report its authors knew of. Headache, dizziness, drowsiness, and diarrhoea are its commonest side effects. Historical description, not medical advice; in a poisoning, call a poison centre.

Pharmacognosy & Toxicology

Constituents
  • kavalactonesalso called kavapyrones, the active constituents
Mechanism
Not established in the sources read for this entry.
Standing
There is no European monograph: the European Medicines Agency’s herbal committee declined one (public statement of 2017), judging the balance of benefit and risk unfavourable. Use is banned or restricted in several countries, among them Germany. A Cochrane review (2003) found it effective for anxiety in the short term.
  • European Medicines Agency, Committee on Herbal Medicinal Products. Public statement on Piperis methystici rhizoma (Kava-kava). EMA/HMPC/450588/2016, 21 November 2017. Read in full · the text read
  • European Medicines Agency, Committee on Herbal Medicinal Products. Assessment report on Piperis methystici rhizoma. EMA/HMPC/450589/2016, 21 November 2017. Read in part · the text read
  • Pittler MH & Ernst E (2003). Kava extract for treating anxiety. The Cochrane database of systematic reviews. PMID 12535473. Abstract read · the text read
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, “KavaKava.” National Institute of Diabetes and Digestive and Kidney Diseases, updated 2018. NCBI Bookshelf. Read in full · the text read

The abstract of each source, beneath its citation. For Club members. About the Club or sign in.

Constituent names open the compound’s record at PubChem, and “ChEMBL” beside a name opens its record at ChEMBL, the European Bioinformatics Institute’s database of bioactive molecules. Where a mechanism line was checked against ChEMBL (ChEMBL 37, read 1 October 2026), the check is shown with the measured value and its source paper, or says plainly that nothing has been measured. Doses are as the references give them, for description only; this is not medical advice. Each source carries the result of its check against Crossref, PubMed, or the authority’s page: see Verification.

Kava: what lore surrounds it?

Grieve reports that continued use in large doses “causes inflammation of the body and eyes, resulting in leprous ulcers; the skin becomes parched and peels off in scales,” and that its effect on the nerve centres is at first stimulating, then depressing.

Kava: what did the older authorities say?

King’s American Dispensatory (1898)
“It was discovered by James Cook, the celebrated explorer, in 1769, in the Tahiti Islands.” The drink was invariably made by chewing the root to a pulp, covering it with water, macerating it a short time, and straining it through a fibre from the bark of a native tree; its taste was said to resemble soap-suds and tannin.

Sources

  • Grieve, M. A Modern Herbal, “Kava Kava.” As published on botanical.com. Read in full · the text read
  • Felter, H. W., & Lloyd, J. U. (1898). King’s American Dispensatory, vol. 2, “Piper Methysticum.” Internet Archive, kingsamericandis02kinguoft. Read in part · the text read
  • European Medicines Agency, Committee on Herbal Medicinal Products. Public statement on Piperis methystici rhizoma (Kava-kava). EMA/HMPC/450588/2016, 21 November 2017. Read in full · the text read
  • European Medicines Agency, Committee on Herbal Medicinal Products. Assessment report on Piperis methystici rhizoma. EMA/HMPC/450589/2016, 21 November 2017. Read in part · the text read
  • Pittler MH & Ernst E (2003). Kava extract for treating anxiety. The Cochrane database of systematic reviews. PMID 12535473. Abstract read · the text read
  • Economidis G, et al. (2025). Global Perspectives on Kava: A Narrative Systematic Review of the Health Effects, Economic and Social Impacts and Policy Considerations. Drug and alcohol review. PMID 40560778. Abstract read · the text read
  • Cassidy RM, et al. (2024). Kava Withdrawal Treated With Phenobarbital-A Case Report and Literature Review. Journal of addiction medicine. PMID 38829029. Abstract read · the text read
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, “KavaKava.” National Institute of Diabetes and Digestive and Kidney Diseases, updated 2018. NCBI Bookshelf. Read in full · the text read

Verification

Checked
October 1, 2026
Passes
  • Every sentence read against its sources, in the pass over the remaining 343 entries
  • The Standing line checked against the authority it names (EMA, WHO, FDA, CITES, Commission E)
  • Every dated or regulatory claim checked by category across the database
Sources
8 cited: 3 read in full, 2 read in part, 3 abstract read. 3 with the abstract on file.
Corrections
None were needed.

What was checked, how, and what was found is set out on the Verification page. A checked source is one whose record was found; it does not make the entry medical advice.

Club members can point at a technical term in this entry, such as a constituent, an action, or a word of Jung’s, to read its definition from the source. The Club.

Cite This Entry

Version 1 · first published October 17, 2026

Chicago

“Kava.” In Materia Medica, edited by B. C. P. Statema. Version 1. The Thinking Press, 2026–. Last modified October 17, 2026. https://thethinkingpress.org/materia-medica/kava.

MLA

“Kava.” Materia Medica, edited by B. C. P. Statema, version 1, The Thinking Press, 17 Oct. 2026, thethinkingpress.org/materia-medica/kava. Accessed 17 Oct. 2026.

APA

Kava. (2026, October 17). In B. C. P. Statema (Ed.), Materia medica (Version 1). The Thinking Press. Retrieved October 17, 2026, from https://thethinkingpress.org/materia-medica/kava

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See Also

Drawing on the same sources: Grieve, Felter

Knotgrass · Juniper · Kola nut · Hedge mustard · Laburnum · the bibliography →

Nearby in the alphabet

Kermes (which yield a red dye used since antiquity) · Juneberry · Koji mould (The mould grown on steamed rice or soybeans) · Jewelweed · Jet, oil of (Jet is a brown coal formed from fossilized wood)

Historical description, not medical advice.