Saw palmetto
Sabal; Sabal serrulata of Grieve; Serenoa repens (W. Bartram) Small; in pharmacy Sabalis serrulatae fructus
- Known today as
- Serenoa repens, a small palm of the family Arecaceae with a creeping, branching stem six to ten feet long and bright-green, fan-shaped leaves on spiny-edged stalks. King’s Dispensatory finds it plentiful along the Atlantic shores from Florida to South Carolina, where it forms the ‘palmetto scrub’ of the coast. The drug is the fruit, a one-seeded, blackish-brown drupe half an inch to an inch long, sweet and edible but, King’s says, not particularly palatable; a single panicle may yield six to eight pounds of berries, and the fresh berries have a characteristic cheesy odour.
- Kind
- Plant, in 1 older authority
- Constituents
- fatty acids, beta-sitosterol, flavonoids
- Earliest authority here
- King’s American Dispensatory (1898)
- In other databases
- Plants of the World Online · GBIF · Wikidata
Caution. Men should see a doctor if their complaints worsen or if fever, spasms, blood in the urine, painful urination, or retention of urine occur. A few cases of suspected interaction with warfarin, with raised INR, have been reported. Abdominal pain and headache are common; nausea, raised liver enzymes, rash, and reversible enlargement of the breasts are uncommon. LiverTox finds it implicated in rare cases of clinically apparent liver injury, its specific role uncertain.
Saw palmetto: what was it used for?
A remedy of the bladder and urethra, and of the prostate. Grieve gives it as diuretic, sedative, and tonic, used for many complaints with chronic catarrh, and records the claim that it could increase “the nutrition of the testicles and mammae in functional atony of these organs”; it probably acted, she thought, by reducing catarrhal irritation and a relaxed condition of the bladder and urethra. LiverTox records that Native Americans used the fruit as food and as a remedy, among other things as a sedative, diuretic, and expectorant and for urinary problems.
Saw palmetto: what does modern science say?
The European Medicines Agency’s herbal committee accepts a hexane soft extract of the fruit on clinical evidence, as ‘well-established use,’ for the symptomatic treatment of benign enlargement of the prostate, and an ethanol soft extract as a traditional herbal medicine, “exclusively based upon long-standing use,” for the lower urinary tract symptoms of the same condition after a doctor has excluded serious conditions (monograph of 2015). Its assessment report finds the fruit rich in fatty acids, free and as esters, with sterols, chiefly beta-sitosterol, and flavonoids. The trials have since turned against it: the Cochrane review of 2023 concluded that saw palmetto alone “provides little to no benefits for men with lower urinary tract symptoms due to benign prostatic enlargement,” on evidence mostly of high or moderate certainty, with more uncertainty about it in combination with other herbs. LiverTox, revised in 2020, likewise notes that short trials suggested benefit, with no effect on prostate size or PSA, while longer studies were less clear.
Pharmacognosy & Toxicology
- Constituents
- fatty acidsfree and as esters, in which the fruit is rich
- beta-sitosterolchief of the sterols
- flavonoids
- Mechanism
- Not established in the sources read for this entry.
- Standing
- European Union herbal monograph (2015): well-established use of a hexane extract and traditional use of an ethanol extract for benign prostatic enlargement. A Cochrane review (2023) found little to no benefit.
- European Medicines Agency, Committee on Herbal Medicinal Products. European Union herbal monograph on Sabalis serrulatae fructus (Saw Palmetto Fruit). EMA/HMPC/280079/2013, 24 November 2015. Read in full · the text read
- European Medicines Agency, Committee on Herbal Medicinal Products. Assessment report on Sabalis serrulatae fructus. EMA/HMPC/137250/2013, 24 November 2015. Read in part · the text read
- Franco JV, et al. (2023). Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement. The Cochrane database of systematic reviews. PMID 37345871. Abstract read · the text read
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, “SawPalmetto.” National Institute of Diabetes and Digestive and Kidney Diseases, updated 2020. NCBI Bookshelf. Read in full · the text read
The abstract of each source, beneath its citation. For Club members. About the Club or sign in.
Constituent names open the compound’s record at PubChem, and “ChEMBL” beside a name opens its record at ChEMBL, the European Bioinformatics Institute’s database of bioactive molecules. Where a mechanism line was checked against ChEMBL (ChEMBL 37, read 1 October 2026), the check is shown with the measured value and its source paper, or says plainly that nothing has been measured. Doses are as the references give them, for description only; this is not medical advice. Each source carries the result of its check against Crossref, PubMed, or the authority’s page: see Verification.
Saw palmetto: what did the older authorities say?
- King’s American Dispensatory (1898)
- Parts of the plant served for thatching huts and making mattresses, straw hats, and paper. Animals show a partiality for the fruit “and are said to become fat and sleek when feeding upon the berries.”
Sources
- Grieve, M. A Modern Herbal, “Saw Palmetto.” As published on botanical.com. Read in full · the text read
- Felter, H. W., & Lloyd, J. U. (1898). King’s American Dispensatory, vol. 2, “Serenoa.” Internet Archive, kingsamericandis02kinguoft. Read in part · the text read
- European Medicines Agency, Committee on Herbal Medicinal Products. European Union herbal monograph on Sabalis serrulatae fructus (Saw Palmetto Fruit). EMA/HMPC/280079/2013, 24 November 2015. Read in full · the text read
- European Medicines Agency, Committee on Herbal Medicinal Products. Assessment report on Sabalis serrulatae fructus. EMA/HMPC/137250/2013, 24 November 2015. Read in part · the text read
- Franco JV, et al. (2023). Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement. The Cochrane database of systematic reviews. PMID 37345871. Abstract read · the text read
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, “SawPalmetto.” National Institute of Diabetes and Digestive and Kidney Diseases, updated 2020. NCBI Bookshelf. Read in full · the text read
Verification
- Checked
- October 1, 2026
- Passes
- Every sentence read against its sources, in the pass over the remaining 343 entries
- The Standing line checked against the authority it names (EMA, WHO, FDA, CITES, Commission E)
- Every dated or regulatory claim checked by category across the database
- Sources
- 6 cited: 3 read in full, 2 read in part, 1 abstract read. 1 with the abstract on file.
- Corrections
- None were needed.
What was checked, how, and what was found is set out on the Verification page. A checked source is one whose record was found; it does not make the entry medical advice.
Club members can point at a technical term in this entry, such as a constituent, an action, or a word of Jung’s, to read its definition from the source. The Club.
Cite This Entry
Version 1 · first published October 17, 2026
- Chicago
“Saw palmetto.” In Materia Medica, edited by B. C. P. Statema. Version 1. The Thinking Press, 2026–. Last modified October 17, 2026. https://thethinkingpress.org/materia-medica/saw-palmetto.
- MLA
“Saw palmetto.” Materia Medica, edited by B. C. P. Statema, version 1, The Thinking Press, 17 Oct. 2026, thethinkingpress.org/materia-medica/saw-palmetto. Accessed 17 Oct. 2026.
- APA
Saw palmetto. (2026, October 17). In B. C. P. Statema (Ed.), Materia medica (Version 1). The Thinking Press. Retrieved October 17, 2026, from https://thethinkingpress.org/materia-medica/saw-palmetto
Club members keep entries on a shelf with private notes, print the plates as cards, and receive an entry by email each week. Create a free account before January 1, 2027 and all of it is yours for good. About the Club
See Also
Sharing flavonoids
Capsella bursa-pastoris · Herniaria glabra · Oxalis acetosella · Buphthalmum salicifolium
Drawing on the same sources: Grieve, Felter
Sage · Skullcap · Sorrel, syrup of · Pumpkin seed · Wild yam · the bibliography →
Nearby in the alphabet
Scammony (The dried root resin of Convolvulus scammonia) · Savin (a low juniper) · Scapular (worn over the shoulders, a miniature of the monastic scapular) · The SATOR square (A five-line Latin word square that can be read in four directions) · Self-heal (Prunella vulgaris) · Sassafras (The root bark of Sassafras albidum) · Senna (The leaves and pods of Senna alexandrina) · Sarsaparilla (thorny climbers of Central and South America)
Historical description, not medical advice.
