Boneset
Thoroughwort, ague-weed; Eupatorium perfoliatum L.
- Known today as
- Eupatorium perfoliatum, of the family Compositae, a stout, hairy perennial two to four feet high of low meadows and damp ground in North America from Nova Scotia to Florida, flowering from July to September in flat heads of many small white florets. Its leaves are unmistakable: each opposite pair is joined at the base so that the stem seems to pass through a single leaf, whence perfoliatum. The leaves and flowering tops are the drug; they are slightly aromatic, astringent, and strongly bitter, and Grieve names a bitter principle, eupatorin.
- Kind
- Plant, in 1 older authority
- Constituents
- eupatorin, tannic acid, volatile oil
- Earliest authority here
- Grieve, A Modern Herbal (1931) (A Modern Herbal, 1931)
- In other databases
- Plants of the World Online · GBIF · Wikidata
Caution. Grieve and King’s both record that in large doses, or as a strong hot infusion, it is emetic and purgative. None of the sources read for this entry reports on its safety as a modern medicine.
Boneset: what was it used for?
A remedy for fevers and colds. Grieve calls it stimulant, febrifuge, and laxative, a mild tonic in moderate doses and diaphoretic as a warm infusion, much esteemed in intermittent fever and used for muscular rheumatism, colds, catarrh, influenza, and the indigestion of old people; in large doses emetic and purgative. King’s explains that the hot infusion was given in intermittent fever to make the patient vomit and sweat freely, and the cold infusion between the attacks as a tonic, and that it was useful in irregular agues “which that drug,” quinine, “does not seem to reach.”
Boneset: what does modern science say?
No European monograph for it was found for this entry. The searches of Europe PMC made for this entry found no clinical trial of the herb itself; the recent clinical studies under its name concern a homoeopathic dilution, a different preparation, and are not used here.
Pharmacognosy & Toxicology
- Constituents
- eupatorina bitter glucosidal principle
- tannic acid ChEMBLsome
- volatile oil
- Mechanism
- Not established in the sources read for this entry.
- Standing
- There is no European monograph. Official in the United States Pharmacopoeia in Grieve’s day; no clinical trial of the herb was found for this entry.
- Grieve, M. A Modern Herbal, “Boneset.” As published on botanical.com. Read in full · the text read
- Felter, H. W., & Lloyd, J. U. (1898). King’s American Dispensatory, vol. 1, “Eupatorium.” Internet Archive, kingsamericandis01kinguoft. Read in part · the text read
Constituent names open the compound’s record at PubChem, and “ChEMBL” beside a name opens its record at ChEMBL, the European Bioinformatics Institute’s database of bioactive molecules. Where a mechanism line was checked against ChEMBL (ChEMBL 37, read 1 October 2026), the check is shown with the measured value and its source paper, or says plainly that nothing has been measured. Doses are as the references give them, for description only; this is not medical advice. Each source carries the result of its check against Crossref, PubMed, or the authority’s page: see Verification.
Boneset: what lore surrounds it?
Grieve corrects the earlier books: many of them called boneset a diuretic for dropsy, “but this is an error,” that property belonging to its purple-flowered relative, gravel root.
Boneset: what did the older authorities say?
- Grieve, A Modern Herbal (1931)
- “Boneset was a favourite medicine of the North American Indians, who called it by a name that is equivalent to ‘Ague-weed,’” and probably no plant in American domestic practice had more frequent use; Grieve adds that it was largely used by Black Americans in the South as a remedy in all fevers. The name, she reports, is said to come from its value in a kind of influenza, common in the United States, “which from the pain attending it was commonly called Break-Bone Fever.”
Sources
- Grieve, M. A Modern Herbal, “Boneset.” As published on botanical.com. Read in full · the text read
- Felter, H. W., & Lloyd, J. U. (1898). King’s American Dispensatory, vol. 1, “Eupatorium.” Internet Archive, kingsamericandis01kinguoft. Read in part · the text read
Verification
- Checked
- October 1, 2026
- Passes
- Every sentence read against its sources, in the pass over the remaining 343 entries
- The Standing line checked against the authority it names (EMA, WHO, FDA, CITES, Commission E)
- Every dated or regulatory claim checked by category across the database
- Sources
- 2 cited: 1 read in full, 1 read in part.
- Corrections
- None were needed.
What was checked, how, and what was found is set out on the Verification page. A checked source is one whose record was found; it does not make the entry medical advice.
Club members can point at a technical term in this entry, such as a constituent, an action, or a word of Jung’s, to read its definition from the source. The Club.
Cite This Entry
Version 1 · first published October 17, 2026
- Chicago
“Boneset.” In Materia Medica, edited by B. C. P. Statema. Version 1. The Thinking Press, 2026–. Last modified October 17, 2026. https://thethinkingpress.org/materia-medica/boneset.
- MLA
“Boneset.” Materia Medica, edited by B. C. P. Statema, version 1, The Thinking Press, 17 Oct. 2026, thethinkingpress.org/materia-medica/boneset. Accessed 17 Oct. 2026.
- APA
Boneset. (2026, October 17). In B. C. P. Statema (Ed.), Materia medica (Version 1). The Thinking Press. Retrieved October 17, 2026, from https://thethinkingpress.org/materia-medica/boneset
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See Also
Sharing tannic acid
Also in M. Grieve
Burdock in M. Grieve · Bloodroot in M. Grieve · Butcher’s broom in M. Grieve · Blackcurrant in M. Grieve · everything M. Grieve names →
Drawing on the same sources: Grieve, Felter
Borage · Boldo · Broom · Borax · Brewer’s yeast · the bibliography →
Nearby in the alphabet
Bogbean · Breve (A written prayer or holy names folded and worn on the body) · Blue cohosh · Bloodstone (iron oxide, which streaks blood-red)
Historical description, not medical advice.

