Boneset

Thoroughwort, ague-weed; Eupatorium perfoliatum L.

Known today as
Eupatorium perfoliatum, of the family Compositae, a stout, hairy perennial two to four feet high of low meadows and damp ground in North America from Nova Scotia to Florida, flowering from July to September in flat heads of many small white florets. Its leaves are unmistakable: each opposite pair is joined at the base so that the stem seems to pass through a single leaf, whence perfoliatum. The leaves and flowering tops are the drug; they are slightly aromatic, astringent, and strongly bitter, and Grieve names a bitter principle, eupatorin.
Kind
Plant, in 1 older authority
Constituents
eupatorin, tannic acid, volatile oil
Earliest authority here
Grieve, A Modern Herbal (1931) (A Modern Herbal, 1931)
In other databases
Plants of the World Online · GBIF · Wikidata

Caution. Grieve and King’s both record that in large doses, or as a strong hot infusion, it is emetic and purgative. None of the sources read for this entry reports on its safety as a modern medicine.

Boneset: what was it used for?

A remedy for fevers and colds. Grieve calls it stimulant, febrifuge, and laxative, a mild tonic in moderate doses and diaphoretic as a warm infusion, much esteemed in intermittent fever and used for muscular rheumatism, colds, catarrh, influenza, and the indigestion of old people; in large doses emetic and purgative. King’s explains that the hot infusion was given in intermittent fever to make the patient vomit and sweat freely, and the cold infusion between the attacks as a tonic, and that it was useful in irregular agues “which that drug,” quinine, “does not seem to reach.”

Boneset: what does modern science say?

No European monograph for it was found for this entry. The searches of Europe PMC made for this entry found no clinical trial of the herb itself; the recent clinical studies under its name concern a homoeopathic dilution, a different preparation, and are not used here.

Pharmacognosy & Toxicology

Constituents
Mechanism
Not established in the sources read for this entry.
Standing
There is no European monograph. Official in the United States Pharmacopoeia in Grieve’s day; no clinical trial of the herb was found for this entry.
  • Grieve, M. A Modern Herbal, “Boneset.” As published on botanical.com. Read in full · the text read
  • Felter, H. W., & Lloyd, J. U. (1898). King’s American Dispensatory, vol. 1, “Eupatorium.” Internet Archive, kingsamericandis01kinguoft. Read in part · the text read

Constituent names open the compound’s record at PubChem, and “ChEMBL” beside a name opens its record at ChEMBL, the European Bioinformatics Institute’s database of bioactive molecules. Where a mechanism line was checked against ChEMBL (ChEMBL 37, read 1 October 2026), the check is shown with the measured value and its source paper, or says plainly that nothing has been measured. Doses are as the references give them, for description only; this is not medical advice. Each source carries the result of its check against Crossref, PubMed, or the authority’s page: see Verification.

Boneset: what lore surrounds it?

Grieve corrects the earlier books: many of them called boneset a diuretic for dropsy, “but this is an error,” that property belonging to its purple-flowered relative, gravel root.

Boneset: what did the older authorities say?

Grieve, A Modern Herbal (1931)
“Boneset was a favourite medicine of the North American Indians, who called it by a name that is equivalent to ‘Ague-weed,’” and probably no plant in American domestic practice had more frequent use; Grieve adds that it was largely used by Black Americans in the South as a remedy in all fevers. The name, she reports, is said to come from its value in a kind of influenza, common in the United States, “which from the pain attending it was commonly called Break-Bone Fever.”

Sources

  • Grieve, M. A Modern Herbal, “Boneset.” As published on botanical.com. Read in full · the text read
  • Felter, H. W., & Lloyd, J. U. (1898). King’s American Dispensatory, vol. 1, “Eupatorium.” Internet Archive, kingsamericandis01kinguoft. Read in part · the text read

Verification

Checked
October 1, 2026
Passes
  • Every sentence read against its sources, in the pass over the remaining 343 entries
  • The Standing line checked against the authority it names (EMA, WHO, FDA, CITES, Commission E)
  • Every dated or regulatory claim checked by category across the database
Sources
2 cited: 1 read in full, 1 read in part.
Corrections
None were needed.

What was checked, how, and what was found is set out on the Verification page. A checked source is one whose record was found; it does not make the entry medical advice.

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Cite This Entry

Version 1 · first published October 17, 2026

Chicago

“Boneset.” In Materia Medica, edited by B. C. P. Statema. Version 1. The Thinking Press, 2026–. Last modified October 17, 2026. https://thethinkingpress.org/materia-medica/boneset.

MLA

“Boneset.” Materia Medica, edited by B. C. P. Statema, version 1, The Thinking Press, 17 Oct. 2026, thethinkingpress.org/materia-medica/boneset. Accessed 17 Oct. 2026.

APA

Boneset. (2026, October 17). In B. C. P. Statema (Ed.), Materia medica (Version 1). The Thinking Press. Retrieved October 17, 2026, from https://thethinkingpress.org/materia-medica/boneset

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See Also

Sharing tannic acid

Oak galls · Viburnum prunifolium

Drawing on the same sources: Grieve, Felter

Borage · Boldo · Broom · Borax · Brewer’s yeast · the bibliography →

Nearby in the alphabet

Bogbean · Breve (A written prayer or holy names folded and worn on the body) · Blue cohosh · Bloodstone (iron oxide, which streaks blood-red)

Historical description, not medical advice.