Leech

Hirudo

Known today as
The medicinal leech, Hirudo medicinalis.
Kind
Animal, in 2 older authorities
Constituents
hirudin, calin, hyaluronidase
Earliest authority here
François Broussais
In other databases
GBIF search · Wikidata search

Revised October 3, 2026: Tradition, lore, modern assessment, and sources extended. Checked against its sources, each read in full, in part, or in its abstract. Version 1, first published September 25, 2026.

Leech: what was it used for?

Bloodletting where the lancet could not go: for inflammations, fevers, and congestion.

Leech: what does modern science say?

Its saliva contains hirudin, an anticoagulant; leeches are used again after reconstructive surgery, and the FDA cleared them as a medical device in 2004. John Haycraft found in 1884 that the leech’s saliva stops blood from clotting; the substance, hirudin, is now made by recombinant techniques for anticoagulant drugs. Plastic surgeons returned to the living leech in the 1970s to drain congested blood from reattached fingers and grafted flaps, and the United States cleared it as a medical device in 2004. The wild leech is protected across Europe.

Pharmacognosy & Toxicology

Constituents
Mechanism
Hirudin binds thrombin directly; the wound goes on bleeding steadily after the leech has detached, which is the surgical use.
Toxic dose
Infection with Aeromonas from the leech’s gut is the hazard; antibiotics are given.
Standing
A medical device in the United States since 2004; recombinant hirudins are licensed anticoagulants.
  • Whitaker, I. S., et al. (2004). British Journal of Oral and Maxillofacial Surgery 42. Book, not indexed

Constituent names open the compound’s record at PubChem, and “ChEMBL” beside a name opens its record at ChEMBL, the European Bioinformatics Institute’s database of bioactive molecules. Where a mechanism line was checked against ChEMBL (ChEMBL 37, read 1 October 2026), the check is shown with the measured value and its source paper, or says plainly that nothing has been measured. Doses are as the references give them, for description only; this is not medical advice. Each source carries the result of its check against Crossref, PubMed, or the authority’s page: see Verification.

Leech: what lore surrounds it?

Wordsworth’s leech-gatherer, in “Resolution and Independence” (1807), old and poor, roamed “from Pond to Pond” and “from moor to moor,” stirring the waters about his feet, and complained that the leeches “have dwindled long by slow decay.” George Merryweather’s “tempest prognosticator,” explained to the Whitby Philosophical Society in 1851, rang a bell when leeches in bottles climbed before a storm.

Leech: what did the older authorities say?

François Broussais
The French army physician reported in 1816 that the fever patients in his wards at the Val-de-Grâce were all cured within days by bleeding and by leeches on the abdomen or the anus, repeated as often as the symptoms grew worse.
The leech-mania
Broussais’s theories made France, which had once exported its surplus leeches, the largest consumer in the world, using fifty to a hundred million a year and importing over fifty-seven million in 1832 alone; the Manchester Royal Infirmary used fifty thousand in 1831, and the harvest across Europe brought local populations almost to extinction.

Sources

  • Broussais, F. J. V. (1816). Examen de la doctrine médicale. Read in part · the text read
  • Wordsworth, W. (1807). “Resolution and Independence.” Read in part · the text read
  • Whitaker, I. S., et al. (2004). “Hirudo medicinalis: ancient origins of, and trends in the use of medicinal leeches throughout history.” British Journal of Oral and Maxillofacial Surgery 42. Abstract read · the text read
  • Wikipedia, “Hirudo medicinalis.” Read in full · the text read
  • Wikipedia, “Hirudin.” Read in full · the text read
  • Wikipedia, “Tempest prognosticator.” Read in full · the text read
  • Copena, D., & Gómez-Martín, M. (2024). Spanish–French leech trade and its consequences: from the increase in medical demand to resource depletion and technical innovation. Medical History 68. Read in full · the text read
  • Singh, S. K., & Rajoria, K. (2020). Medical leech therapy in Ayurveda and biomedicine: a review. Journal of Ayurveda and Integrative Medicine 11. Read in full · the text read

Verification

Checked
October 1, 2026, and October 3, 2026
Passes
  • Every sentence read against its sources, in the pass over the remaining 343 entries
  • The Standing line checked against the authority it names (EMA, WHO, FDA, CITES, Commission E)
  • Every dated or regulatory claim checked by category across the database
  • Every source read, in full, in part, or in its abstract, and every sentence checked against what was read (October 3, 2026)
Sources
9 cited: 5 read in full, 2 read in part, 1 abstract read, 1 book, not indexed. 1 with the abstract on file.
Corrections
None were needed.

What was checked, how, and what was found is set out on the Verification page. A checked source is one whose record was found; it does not make the entry medical advice.

Cite This Entry

Version 1 · first published September 25, 2026 · last revised October 3, 2026

Chicago

“Leech.” In Materia Medica, edited by B. C. P. Statema. Version 1. The Thinking Press, 2026–. Last modified October 3, 2026. https://thethinkingpress.org/materia-medica/leech.

MLA

“Leech.” Materia Medica, edited by B. C. P. Statema, version 1, The Thinking Press, 3 Oct. 2026, thethinkingpress.org/materia-medica/leech. Accessed 8 Oct. 2026.

APA

Leech. (2026, October 3). In B. C. P. Statema (Ed.), Materia medica (Version 1). The Thinking Press. Retrieved October 8, 2026, from https://thethinkingpress.org/materia-medica/leech

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See Also

Drawing on the same sources: Wikipedia

Madder · Kermes · Madonna lily · the bibliography →

Nearby in the alphabet

Lenitive electuary · Lavender (L) · Lesser bean-trefoil (Anagyris foetida, a Mediterranean shrub) · Laurel (Laurus nobilis) · Letters from Heaven · Laudanum (with saffron, cinnamon, and cloves) · Licorice (The root of Glycyrrhiza glabra) · Lapis lazuli, pills of

Historical description, not medical advice.