Ginkgo

Chinese yin-hsing, and for the seeds pai-kuo, ‘white fruits’; Salisburia adiantifolia of Stuart; Ginkgo biloba L.; in pharmacy Ginkgo folium

Known today as
Ginkgo biloba, of the family Ginkgoaceae, a tree which Stuart, in 1911, found growing south of the Yangtse, twenty to thirty feet high, “with thin, vertical leaves resembling a duck’s foot (triangular-fan-shaped).” Its name, he explains, comes from the Japanese reading of the Chinese characters yin-kuo. He calls it “a tree of great beauty,” successfully transplanted to Europe and America. The drug of modern pharmacy is the leaf; the Chinese medicine of Stuart’s day used the nut-like seeds.
Kind
Plant, in 1 older authority
Constituents
ginkgolides, bilobalide, flavonoids, and 1 more
Earliest authority here
Stuart, Chinese Materia Medica (1911)
In other databases
Plants of the World Online · GBIF · Wikidata

Caution. Not in pregnancy, since it may impair the clotting of the blood, nor in breast-feeding. Ginkgo may increase the tendency to bleed: people with a bleeding disorder or on anticoagulant or antiplatelet drugs should use it only after consulting a doctor, and it should be stopped three to four days before surgery; bleeding of the eye, nose, brain, and gut has been reported. It may provoke seizures in epilepsy, is not recommended with efavirenz, may raise exposure to dabigatran and nifedipine, and very commonly causes headache. LiverTox, revised in 2018, finds it has not been implicated in liver injury.

Ginkgo: what was it used for?

In Chinese medicine, the seed; in Europe, an extract of the leaf for the circulation and the memory. Stuart records that the seeds, with a somewhat fishy taste, “are supposed to benefit asthma, coughs, irritability of the bladder,” and uterine fluxes, that cooked they were thought digestive and good against worms, and that the Japanese used them likewise to promote digestion.

Ginkgo: what does modern science say?

The European Medicines Agency’s herbal committee accepts a defined dry extract of the leaf, made with 60 per cent acetone, on clinical evidence, as ‘well-established use,’ for the improvement of age-associated cognitive impairment and of quality of life in mild dementia, and the powdered leaf as a traditional herbal medicine, “exclusively based upon long-standing use,” for heavy legs and cold hands and feet in minor circulatory disorders, once a doctor has excluded serious conditions (monograph of 2015). Its assessment report names the ginkgolides and bilobalide and the flavonoids as characteristic constituents, with ginkgolic acids among the minor ones. The Cochrane review of 2026, of 82 trials in 10,613 people, divides the cognitive claim: in dementia there may be small to moderate benefits at six months for global status, cognition, and daily living, on low-certainty evidence, while in mild cognitive impairment ginkgo probably has little or no effect. Other Cochrane reviews found no clinically significant benefit in intermittent claudication (2013), little to no effect on tinnitus on very uncertain evidence (2022), and an unanswered question in macular degeneration (2013).

Pharmacognosy & Toxicology

Constituents
Mechanism
Not established in the sources read for this entry.
Standing
European Union herbal monograph (2015): well-established use of a defined dry extract for age-associated cognitive impairment and mild dementia, and traditional use, “exclusively based upon long-standing use,” of the powdered leaf for minor circulatory disorders. Cochrane (2026) finds small benefits in dementia on low-certainty evidence and little or none in mild cognitive impairment.
  • European Medicines Agency, Committee on Herbal Medicinal Products. European Union herbal monograph on Ginkgo folium (Ginkgo leaf). EMA/HMPC/321097/2012, 28 January 2015. Read in full · the text read
  • European Medicines Agency, Committee on Herbal Medicinal Products. Assessment report on Ginkgo folium. EMA/HMPC/321095/2012, 28 January 2014. Read in part · the text read
  • Wieland LS, et al. (2026). Ginkgo biloba for cognitive impairment and dementia. The Cochrane database of systematic reviews. PMID 41641880. Abstract read · the text read
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, “Ginkgo.” National Institute of Diabetes and Digestive and Kidney Diseases, updated 2018. NCBI Bookshelf. Read in full · the text read

The abstract of each source, beneath its citation. For Club members. About the Club or sign in.

Constituent names open the compound’s record at PubChem, and “ChEMBL” beside a name opens its record at ChEMBL, the European Bioinformatics Institute’s database of bioactive molecules. Where a mechanism line was checked against ChEMBL (ChEMBL 37, read 1 October 2026), the check is shown with the measured value and its source paper, or says plainly that nothing has been measured. Doses are as the references give them, for description only; this is not medical advice. Each source carries the result of its check against Crossref, PubMed, or the authority’s page: see Verification.

Ginkgo: what lore surrounds it?

Raw, the seeds were said by the Chinese to destroy cancer and to counter drunkenness; they were also used to wash clothes. Stuart adds the warning that in some cases they appeared to cause peculiar symptoms of intoxication, “and occasionally to destroy life.”

Ginkgo: what did the older authorities say?

Stuart, Chinese Materia Medica (1911)
“In the second month the tree blooms with a greenish-white bud, which opens in the night and quickly drops off, so that men rarely see the flower on the tree.” The Chinese said that seeds with three ridges grew into male trees and those with two into female, so both kinds should be planted together. The nuts were eaten at weddings, their shells dyed red, and much used at feasts.

Sources

  • Stuart, G. A. (1911). Chinese Materia Medica: Vegetable Kingdom, “Salisburia adiantifolia.” Internet Archive, chinesemateriame00stuauoft. Read in part · the text read
  • European Medicines Agency, Committee on Herbal Medicinal Products. European Union herbal monograph on Ginkgo folium (Ginkgo leaf). EMA/HMPC/321097/2012, 28 January 2015. Read in full · the text read
  • European Medicines Agency, Committee on Herbal Medicinal Products. Assessment report on Ginkgo folium. EMA/HMPC/321095/2012, 28 January 2014. Read in part · the text read
  • Wieland LS, et al. (2026). Ginkgo biloba for cognitive impairment and dementia. The Cochrane database of systematic reviews. PMID 41641880. Abstract read · the text read
  • Nicolaï SP, et al. (2013). Ginkgo biloba for intermittent claudication. The Cochrane database of systematic reviews. PMID 23744597. Abstract read · the text read
  • Sereda M, et al. (2022). Ginkgo biloba for tinnitus. The Cochrane database of systematic reviews. PMID 36383762. Abstract read · the text read
  • Evans JR (2013). Ginkgo biloba extract for age-related macular degeneration. The Cochrane database of systematic reviews. PMID 23440785. Abstract read · the text read
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, “Ginkgo.” National Institute of Diabetes and Digestive and Kidney Diseases, updated 2018. NCBI Bookshelf. Read in full · the text read

Verification

Checked
October 1, 2026
Passes
  • Every sentence read against its sources, in the pass over the remaining 343 entries
  • The Standing line checked against the authority it names (EMA, WHO, FDA, CITES, Commission E)
  • Every dated or regulatory claim checked by category across the database
Sources
8 cited: 2 read in full, 2 read in part, 4 abstract read. 4 with the abstract on file.
Corrections
None were needed.

What was checked, how, and what was found is set out on the Verification page. A checked source is one whose record was found; it does not make the entry medical advice.

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Cite This Entry

Version 1 · first published October 17, 2026

Chicago

“Ginkgo.” In Materia Medica, edited by B. C. P. Statema. Version 1. The Thinking Press, 2026–. Last modified October 17, 2026. https://thethinkingpress.org/materia-medica/ginkgo.

MLA

“Ginkgo.” Materia Medica, edited by B. C. P. Statema, version 1, The Thinking Press, 17 Oct. 2026, thethinkingpress.org/materia-medica/ginkgo. Accessed 17 Oct. 2026.

APA

Ginkgo. (2026, October 17). In B. C. P. Statema (Ed.), Materia medica (Version 1). The Thinking Press. Retrieved October 17, 2026, from https://thethinkingpress.org/materia-medica/ginkgo

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See Also

Drawing on the same sources: Stuart

Ginseng · Dong quai · Goji berry · the bibliography →

Nearby in the alphabet

Ginger (The rhizome of Zingiber officinale) · Glass powder (Powdered glass) · Ghost pipe · Glauber’s salt · Gentian · Goat’s rue (French lilac) · Garlic (Allium sativum)

Historical description, not medical advice.