The drastic resins
Scammony, colocynth (cucurbitacins), gamboge (gambogic acid), jalap, turpeth, the larch agaric (agaricic acid), and the Galenic compounds that stacked them: Cochia and golden pills, hamech, diaphenicon, the hieras.
The drastic resins: how soon does it show?
One to four hours.
How does it run?
Violent colic, vomiting, and copious watery stools, often bloody, from direct irritation of the whole gut; dehydration, collapse, and in the worst cases death, as in the Morison’s pill cases of the 1830s (gamboge) and the colocynth deaths of the pharmacopoeial era. The Galenists held these drew the deep humours, and read the violence as strength.
What is done for it?
Fluids and salts; demulcents; nothing specific.
Historical and descriptive, not medical advice. In a poisoning, call a poison centre or emergency services.
Which substances in the database cause it?










Sources
- Goldfrank’s Toxicologic Emergencies, 11th ed. (2019), “Herbal preparations.” Standard reference work
- Helfand, W. H. (1974). “James Morison and his pills.” Transactions of the British Society for the History of Pharmacy 1. Not indexed
- Chen, J. C., et al. (2005). “Cucurbitacins and cucurbitane glycosides: structures and biological activities.” Natural Product Reports 22. Verified against its record · doi:10.1002/chin.200539234