Tropane (anticholinergic) poisoning

Atropine, hyoscyamine, and scopolamine: mandrake, henbane, deadly nightshade, thorn-apple.

Tropane (anticholinergic) poisoning: how soon does it show?

Thirty minutes to a few hours; longer from the skin.

How does it run?

“Red as a beet, dry as a bone, blind as a bat, hot as a hare, mad as a hatter”: flushing, dry mouth, dilated pupils, fever, a fast heart, delirium with vivid hallucination and no memory of it, then coma. The flying ointments of the witches worked by these.

What is done for it?

Physostigmine, the specific antidote, with care; benzodiazepines; cooling.

Historical and descriptive, not medical advice. In a poisoning, call a poison centre or emergency services.

Which substances in the database cause it?

Sources

  • Goldfrank’s Toxicologic Emergencies, 11th ed. (2019), “Anticholinergics.” Standard reference work
  • Nelson, L. S., et al. (2007). Handbook of Poisonous and Injurious Plants, 2nd ed. Verified against its record · doi:10.1007/978-1-4939-8926-3